Research on Alcoholic Liver Disease and Liv-52
Liv.52 enhances the absorption of ethanol and rapidly reduces the acetaldehyde levels, which may explain its hepatoprotective effect on ethanol-induced liver damage8,9. Keeping these facts in mind, a study was undertaken to elucidate the protective effect, if any, of Liv.52 against the harmful effects of maternal alcohol consumption during the gestation period and also to determine the effect of Liv.52 on the acetaldehyde concentrations in the amniotic fluid of fetuses. To read more about this study, visit Protective effect of Liv.52 on alcohol-induced fetotoxicity - Gopumadhavan, S., Jagadeesh, S., Chauhan, B.L. and Kulkarni, R.D., Alcoholism: Clinical and Experimental Research (1993): (17), 5, 1089.
Liv.52 produced a considerable reduction in blood and urine levels of ethanol and acetaldehyde after 12 hours. It is possible that Liv.52 prevents the binding of acetaldehyde, bringing about higher initial blood levels followed by rapid elimination. It reduced the hangover symptoms. To read more about this study, visit Alcohol hangover and Liv.52 - Chauhan, B.L. and Kulkarni, R.D., European Journal of Clinical Pharmacology (1991): 40, 187.
Whisky 120ml consumed by regular alcohol users in 1h, before and following 15 days of Liv.52 treatment produced significantly higher ethanol levels at 2, 3 and 4 h and significantly lower acetaldehyde levels at 3 and 4 h after Liv.52 treatment. Liv52 enhanced the rate of absorption of ethanol and rapidly reduced acetaldehyde levels, which may explain its hepatoprotective effect on ethanol-induced liver damage.To read more about this study, visit Effect of Liv.52, a herbal preparation, on absorption and metabolism of ethanol in humans - Chauhan, B.L. and Kulkarni, R.D., European Journal of Clinical Pharmacology (1991): 40, 189.
Significantly higher ethanol levels were observed after ingestion of Rum and ethanol levels were lowest with Beer. Acetaldehyde levels correlated well with ethanol levels on day 0. Irrespective of type of alcoholic beverage consumed, Liv.52 treatment for 15 days significantly reduced blood acetaldehyde and increased urinary excretion four fold. The possibility of destabilisation of acetaldehyde protein adducts in liver with Liv.52 treatment could be the probable mechanism in reducing the blood acetaldehyde levels in moderate alcohol users. To read more about this study, visit Blood, urine ethanol and acetaldehyde levels from six different alcoholic beverages and effect of Liv.52 - Kulkarni, R.D. and Chauhan, B.L., European Journal of Pharmacology (1990): (183), 5, 1865.
All research studies and clinical trials on efficacy of Liv-52 in Alcoholic Liver Diseases
- Role
of Liv.52 - A herbal formulation on 14C-Ethanol metabolism and
14C-Acetaldehyde accumulation in rat liver (pdf)
Singh, B., Department of Nuclear Medicine,
PGIMER, Chandigarh, Punjab, and Dhawan, D., Department of Biophysics,
Panjab University, Chandigarh, Punjab, Indian Journal of Nuclear
Medicine (2000): (15), 1, 27.
- Hepatoprotective
effects of Liv.52 on ethanol-induced liver damage in rats (pdf)
Rajat Sandhir and Gill, K.D., Department
of Biochemistry, Postgraduate Institute of Medical Education and
Research, Chandigarh, Haryana, Indian Journal of Experimental
Biology (1999): (37), August, 762.
- Effect
of the hepatoprotective drug Liv.52 on liver damage (pdf)
M. Kalab, T. Krechler Internal Clinic
of the Medical Faculty of the Charles University in Prague and
The Military Faculty Hospital in Prague, The
Journal of Czech Physicians (1997): (136), 24, 758-760.
- Bioassay
for evaluation of the hepatoprotective effect of Liv.52, a polyherbal
formulation, on ethanol metabolism in chronic alcohol – Exposed
rats (pdf)
Chauhan, B.L., Mohan, A.R., Kulkarni,
R.D. and Mitra, S.K., R&D Centre, The Himalaya Drug Co., Bangalore,
Karnataka, Indian Journal of Pharmacology (1994): (26), 117.
- Protective
effect of Liv.52 on alcohol-induced fetotoxicity (pdf)
Gopumadhavan, S., Jagadeesh, S., Chauhan,
B.L. and Kulkarni, R.D., R&D Centre, The Himalaya Drug Co.,
Bangalore, Karnataka, Alcoholism:
Clinical and Experimental Research (1993): (17), 5, 1089.
- Alcoholic
liver disease – The possibility of ayurvedic therapy (pdf)
Kulkarni, R.D., Clinical Pharmacology,
Bombay, Maharashtra, The Journal of General Medicine (1992): (4),
2, 11.
- Alcohol
hangover and Liv.52 (pdf)
Chauhan, B.L. and Kulkarni, R.D., R&D
Centre, The Himalaya Drug Co., Bombay, Maharashtra, European
Journal of Clinical Pharmacology (1991): 40, 187.
- Effect
of Liv.52, a herbal preparation, on absorption and metabolism
of ethanol in humans (pdf)
Chauhan, B.L. and Kulkarni, R.D., R&D
Centre, The Himalaya Drug Co., Bombay, Maharashtra, European
Journal of Clinical Pharmacology (1991): 40, 189.
- Dose
response of ethanol after chronic administration of alcohol and
effect of Liv.52 on blood, liver ethanol and acetaldehyde levels
in rats (pdf)
Chauhan, B.L. and Kulkarni, R.D., R&D
Centre, The Himalaya Drug Co., Bombay, Maharashtra, European
Journal of Pharmacology (1990): (183), 5, 1864.
- Blood,
urine ethanol and acetaldehyde levels from six different alcoholic
beverages and effect of Liv.52 (pdf)
Kulkarni, R.D. and Chauhan, B.L., R&D
Centre, The Himalaya Drug Co., Bombay, Maharashtra, European
Journal of Pharmacology (1990): (183), 5, 1865.
- Addiction
and industry (pdf)
Alan De Sousa, J.J. Hospital and Grant
Medical College, Bombay, Maharashtra, Industrial Psychiatry Journal
(1989): 2, 1, 5.
- Liv.52
in alcoholism (pdf)
Alan De Souza, Prakash Gangdev, Ashok
Sinorawala and Manoj Agrawal, Department of Psychiatry, Grant
Medical College and J.J. Hospital, Bombay, Maharashtra, Journal
of Communication Psychiatry (1989): (12), Jan./Mar., 23.
- Injurious
effects of ethyl alcohol on liver function and protective effect
of Liv.52 (pdf)
Doshi, B.S. and Kulkarni, R.D., The Indian
Practitioner (1987): Nov., 965.
- The
mechanism of cellular damage in alcoholic liver disease and the
protective action of Liv.52 (pdf)
Soman, R.N., Bhatia General Hospital,
Tardeo, Bombay, Maharashtra, Probe (1983): (XXII), 3, 164.
- Effect
of ethanol on liver function and its relation to hangover: Protective
effect of Liv.52 (pdf)
Kulkarni, R.D., Grant Medical College,
Bombay, Maharashtra, Indian Drugs (1980): 11, 363.
- Electron
microscopic study of the liver after prolonged use of alcohol (pdf)
Prasad, G.C., Department of Shalya Shalakya
and Surgical Research Laboratory, Institute of Medical Sciences,
Banaras Hindu University, Varanasi, Uttar Pradesh, Probe (1980):
(XIX), 3, 179.
- Effect
of Liv.52 on different bio-chemical parameters in alcoholic cirrhosis (pdf)
Dubey, G.P., Aruna Agrawal and Dixit,
S.P., Department of Basic Principles, Institute of Medical Sciences,
Banaras Hindu University, Varanasi, Uttar Pradesh, The Antiseptic
(1977): (91), 6, 205.
- Effect
of an indigenous drug Liv.52 against alcohol-induced hepatic damage
– A biochemical study (pdf)
Subbarao, V.V., Department of Physiology
and Biochemistry, S.N. Medical College, Jodhpur, Rajasthan, Probe
(1976): (XV), 4, 235.
- Prolonged
moderate alcohol intake and liver function (pdf)
Damle, V.B., L.T.M.G. Hospital and L.T.M.
College, Sion, and Kulkarni, R.D., Grant Medical College and J.J.
Group of Hospitals, Bombay, Maharashtra, Probe (1973): (XIII),
1, 31.
- Effect
of Liv.52 on growth and alcohol-induced hepatic dysfunction in
rats (pdf)
Kale, A.K., Kulkarni, S.D. (Mrs.), Joglekar,
G.V. and Balwani, J.H., B.J. Medical College, Poona, Maharashtra,
Current Medical Practice (1966): (10), 240.
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