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Efficacy of Liv-52 Against Drugs that Cause Liver Damage

Animals treated with the combination of INH, rifampicin and pyrazinamide showed a significant increase in liver peroxide contents, and a significant decrease on SOD, CAT, GPX and GST activities. Also the glutathione level was significantly reduced. Treatment with Liv.52 (500mg/kg, p.o.) significantly modified the hepatotoxic effect of the antitubercular drugs. As shown in Table 2, Liv.52 afforded protection against lipid peroxidation, the above-mentioned parameters being almost restored to normal values. To read more about this study, visit Hepatoprotective effect of Liv.52 on antitubercular drug-induced hepatotoxicity in rats - Vijaya Padma, V, Suja, V. and Shyamala Devi, C.S., Fitoterapia (1998): (LXIX), 6, 520.

Liv.52 improves the function of hepatocytes and promotes the regeneration of the necrosed cells, thereby improving the protein synthesis. It diminishes the activity of serum transaminases and arrests the cell necrosis and inflammation. It is observed histologically in Group I cases the persistence of necrotic changes, granulomata formation progressing to stellate fibrosis, which is not seen in Group II cases. Therefore it can be said that Liv.52 restores normal liver functions earlier and in shorter duration, improves appetite, gives sense of well being, is anti-inflammatory and effectively contributes to healthy repair and regeneration of liver cells which proves its hepato-protective role.To read more about this study, visit Hepatoprotective role of indigenous drug Liv.52 in lepromatous leprosy - Pranesh Nigam and Mukhija, R.D., Hansenlogia Internationalis, Brazil (1982): (7), 1, 36.

All research studies and clinical trials on efficacy of Liv-52 against medications that cause liver damage

  1. Effect of spirulina and Liv.52 on cadmium Indiuced toxicity in albino rats (pdf)
    K Jeyaprakash & P Chinnaswamy Department of Biochemistry, Dr.N.G.P.Arts & Science College, Kovai Medical Center Research & Educational Trust, Coimbatore 641 014, India.


  2. Effect of hepatoprotective agent Liv.52 on nutrition parameters in hemodialysis patients (pdf)
    Gordana Perunicic-Pekovic, Ljiljana Komadina, Steva Pljesa, Zorica Rasic-Milutinovic, Rodoljub Markovic, Department of Nephrology, University Hospital, Zemun-Belgrade and Natasa Milic, Institute of Statistics, Belgrade Medical School, Zemun-Belgrade, Medicine Update - Anniversary Issue, 2003, pp. 52-56.


  3. Protective effect of Liv.52 on Na+-K+-ATPase activity in paracetamol-induced hepatotoxicity (pdf)
    Kala Suhas Kulkarni*, Md. Rafiq, Gopumadhavan, S., Venkataranganna, M.V., Madhumathi, B.G. and Mitra, S.K. R&D Center, The Himalaya Drug Company, Makali, Bangalore, India, Medicine Update (2002): (10), 5, 53-56.


  4. Therapeutic efficacy of Liv.52 in paracetamol induced hepatopathy in rabbits (pdf)
    Anup Bhaumik and Sharma, M.C. Division of Experimental Medicine and Surgery, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India, Indian Journal Veterinary Research (2002): (11), 1, 8-17.


  5. Hepatoprotective effect of Liv.52 on antitubercular drug-induced hepatotoxicity in rats (pdf)
    Vijaya Padma, V, Suja, V. and Shyamala Devi, C.S. Department of Biochemistry, University of Madras, Guindy Campus, Madras, India. and Prema, Head-Department of Biochemistry, Tuberculosis Research Centre, Chetpet, Chennai, India, Fitoterapia (1998): (LXIX), 6, 520.


  6. Effect of phytotherapy on prevention and elimination of hepatotoxic reactions in patients with pulmonary tuberculosis and carriers of hepatitis B virus markers (pdf)
    Galitsky, L.A., Barnaulov, O.D., Zaretskii, B.V., Malkov, M.I., Konenkov, S.I., Gol’m, N.P., Tomakov, V.S., Ogarkov, P.I. and Batskov, S.S. Military Academy of Medicine, Human Brain Institute of the Russian Academy of Sciences, Saint-Petersburg, Russia, Problems of Tuberculosis, (1997): 4, 35.


  7. Hepatoprotective role of Liv.52 against hepatitis-induced by antitubercular drugs (pdf)
    Ashish Khare, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, Probe (1992): (XXXI), 3, 260.


  8. Efficacy of Liv.52 and Geriforte as adjuvant in various carcinomas (pdf)
    Durgesh Kumar Acharya, Regional Centre for Cancer Research and Treatment, Cuttack, Orissa, Probe (1986): (XXV), 3, 249.


  9. Role of Liv.52 in cyclophosphamide-induced alopecia (pdf)
    Harbans Lal Kapoor, Seam, R.K. and Sanjiv Sharma, Department of Radiation Therapy and Oncology, Indira Gandhi Medical College, Simla, Himachal Pradesh, Probe (1986): (XXV), 4, 344.


  10. Hepatoprotective role of indigenous drug Liv.52 in lepromatous leprosy (pdf)
    Pranesh Nigam and Mukhija, R.D., B.R.D. Medical College, Gorakhpur, Dayal, S.G., Government Medical College, Jammu-Tawi, Goyal, B.M. and Joshi, L.D., M.L.B. Medical College, Jhansi, Madhya Pradesh, Hansenlogia Internationalis, Brazil (1982): 7, 1, 36.


  11. Experience with Liv.52 as an adjuvant to anti-tubercular treatment (pdf)
    Vinod Kumar Gupta, The Sincere Dispensary and Nursing Home, Rori Bazar, Sirsa, Haryana, Capsule (1980): 6, 122.


  12. Effect of Liv.52 on hepatic enzymes (pdf)
    Alok Saxena and Garg, N.K., Division of Biochemistry, Central Drug Research Institute, Lucknow, Uttar Pradesh, Indian Journal of Experimental Biology (1979): 7, 662.


  13. The effect of Liv.52 on liver functions of tubercular patients receiving second line anti-tubercular drugs (pdf)
    Brij Kishore, Hazra, D.U., Sachan, A.S., Agrawal, B.M., Bharadwaj, Ashok Kumar and Mehrotra, M.M.N., Postgraduate Department of Medicine, S.N. Medical College, Agra, Uttar Pradesh, Probe (1978): (XVII), 2, 125.


  14. Some observations with Liv.52 therapy in cases of malignancy (pdf)
    Harish Kulkarni, R.S.T. Cancer Centre, Nagpur, Maharashtra, Probe (1978): (XVII), 3, 233.


  15. Effect of an indigenous (herbal) drug Liv.52 on the hepatic damage caused by oral contraceptives – A biochemical (enzymatic) approach (pdf)
    Khuteta, K.P., Upgraded Department of Physiology and Biochemistry, S.M.S. Medical College, Jaipur, Rajasthan, Probe (1978): (XVII), 2, 115.


  16. Leprous hepatitis: Clinico-pathological study and therapeutic efficacy of Liv.52 (pdf)
    Pranesh Nigam, Dayal, S.G., Goyal, B.M., Nimkhedakar, K., Joshi, L.D. and Samuel K.C., M.L.B. Medical College, Jhansi, Uttar Pradesh, Leprosy in India (1978): (50), 2, 185.


  17. Tissue culture and electron microscopic study on regeneration of liver with Liv.52 (pdf)
    Prasad, G.C., Department of Shalya and Surgical Research Laboratory, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh,Capsule (1978): 6, 122.


  18. Liv.52-induced modification of barbiturate hypnosis in albino rats (pdf)
    Joglekar, G.V., Saraf, A.P., Moholkar, A.L. and Shirole, M.V. (Miss.), Department of Pharmacology, B.J. Medical College, Pune, Maharashtra, Maharashtra Medical Journal (1977): (XXIV), 2, 67.


  19. Paracetamol-induced hepatotoxicity and the protective effect of Liv.52 (pdf)
    Mujumdar, S.M. and Kulkarni, R.D., Department of Pharmacology, B.J. Medical College, Pune, Maharashtra, The Indian Practitioner (1977): (XXX), November, 479.


  20. Anorexia in osteoarticular tuberculosis (pdf)
    Dabral, P.K., Srivastava, M.K. and Madhu Dabral (Mrs.), M.L.B. Medical College, Jhansi, Madhya Pradesh, Probe (1976): (XV), 3, 199.


  21. Electron microscopic study on the effect of Liv.52 on carbon tetrachloride treated liver (pdf)
    Prasad, G.C., Department Shalya and Surgical Research Laboratory, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, Journal of Research in Indian Medicine, Yoga and Homeopathy (1976): 4, 38.


  22. Role of Liv.52 in hepatomegaly associated with childhood tuberculosis (A clinico-histopathological study) (pdf)
    Kumar, P. and Shishupal Ram, Department of Paediatrics, Patna Medical College Hospital, Patna, Bihar, The Indian Practitioner (1975): 10, 535.


  23. Place of Liv.52 as an adjuvant to chemotherapy of malignant diseases (pdf)
    Munuswamy, G. and Gajraj, A., Barnard Institute of Radiology and Cancer, Government General Hospital and Madras Medical College, Madras, Tamil Nadu, Probe (1975): (XV), 1, 1.


  24. Effect of Liv.52 on the liver in vitro (pdf)
    Prasad, G.C., Department of Shalya and Surgical Research Laboratory, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, Journal of Research in Indian Medicine (1975): 4, 15.


  25. Effect of Liv.52 on regeneration of liver cells in tissue culture – A preliminary report (pdf)
    Prasad, G.C., Department of Shalya Shalakya and Surgical Research Laboratory, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, Journal of Research in Indian Medicine (1974): (9), 2, 60.


  26. Liv.52 as adjuvant therapy with hepatotoxic and cytotoxic drugs (pdf)
    Vaidya, M.D., Katra Hospital, Mandla, Madhya Pradesh, Probe (1974): (XIII), 2, 73.


  27. Liv.52 improves thioacetazone tolerance (pdf)
    Major Jayaram, C.N., T.B. Sanatorium, Austinpatti, Madurai, Tamil Nadu, Probe (1969): (VIII), 4, 160.



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